The venture capital landscape is poised for significant transformation in 2025. As we navigate through the aftermath of the 2021 bubble and witness the emergence of new investment paradigms, several key trends are likely to reshape the industry. Here's a detailed analysis of what I expect to see this year.
We finally see the full effect of the 2021 bubble
The repercussions of the 2021 investment bubble will finally reach their conclusion in 2025. We'll see the full extent of markdowns and shutdowns, with some particularly surprising closures expected (we’ve already seen a few such as Bench).
Private Equity's Growing Influence
A notable shift is occurring as Private Equity firms increasingly target venture-backed companies. These companies, while no longer exhibiting the explosive growth typical of venture investments, still represent attractive opportunities for PE firms. While this is not new (according to Institutional Investor, The number of PE buyouts of venture-capital-backed startups grew at an annual rate of 18.1% between 2000 and 2019), I expect acceleration this year.
Micro-VC Landscape Transformation
The micro-VC sector is heading toward a fascinating bifurcation that illustrates broader trends in venture capital. During the bull market of 2019-2021, we witnessed an unprecedented surge in first-time fund managers launching micro-VC funds, often with $25-100 million in capital. These managers were buoyed by a combination of excess liquidity in the market, strong paper returns from existing venture portfolios, and heightened interest from limited partners seeking exposure to early-stage technology investments.
In 2025, I think approximately half of micro-cap managers who raised in 18-21 will raise another fund.
Yet paradoxically, 2025 will simultaneously mark one of the most active years for new fund formation for individuals spinning out of larger firms. These spinouts are often $50MM-$400MM funds, with the managers driven by a desire for greater autonomy, more focused investment mandates, or the opportunity to capture better economics.
The Rise of VC Secondaries
The secondary market in venture capital is entering a new phase of maturity. We'll see:
New dedicated secondary investment firms emerging (i.e. Pinegrove).
Existing firms expanding their scope and size.
Record levels of continuation funds and strip sales, and technology that surfaces to help drive efficiency.
Institutional Evolution
Major VC firms will begin to mirror private equity giants like Blackstone, Apollo, and KKR, developing diverse product lines and business units.
At least one prominent VC firm will launch a dedicated private equity product.
Capital will continue to concentrate among select firms across different size ranges.
High-quality managers with strong brands will see their funds substantially oversubscribed.
The Growing Influence of Alternative Capital Sources
Family offices and international wealth channels will strengthen their position in both direct startup investments and fund commitments. This diversification of capital sources brings new perspectives and opportunities to the ecosystem.
Additionally, debt financing (both working capital and venture debt) will continue to grow in usage as equity markets remain tight for the vast majority of companies (buyer beware here as overleveraging is a key risk).
Technology and Sector-Specific Predictions
Artificial Intelligence
The AI sector will achieve another breakthrough year, particularly in:
Intelligent agents (25% of Fortune 500 companies are expected to integrate agents by year-end)
Vertical AI applications in law, medicine, financial services, and space technology
Decreasing costs for training
Record rounds raised by large LLM
IPO Market Revival
The long-awaited thaw in the IPO market will begin in Q2, featuring several companies achieving market capitalizations exceeding $30 billion. This revival will provide much-needed liquidity for LPs and GPs.
Biotech
Biotechnology will emerge as one of the most dynamic sectors for innovation and investment, driven by digital transformation and technological convergence. The intersection of AI, machine learning, and biological sciences will create unprecedented opportunities for breakthrough developments.
Conclusion
These predictions speak to a venture capital ecosystem that's becoming more sophisticated, diverse, and institutionalized while maintaining its core focus on fostering innovation and supporting transformative technologies.
Yes! “Biotechnology will emerge as one of the most dynamic sectors for innovation and investment, driven by digital transformation and technological convergence. The intersection of AI, machine learning, and biological sciences will create unprecedented opportunities for breakthrough developments.”
Nice piece, Samir! Yesterday, I had some strong thoughts regarding the destructive role of secondaries: https://sergeiai.substack.com/p/digital-health-in-2025-expect-massive